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Yes, and the combination has biological support

These are commonly referred to as ROS

Boneberg et al., 2006

21,22 In addition, CYP-derived EETs also regulate some cellular processes of carcinogenesis and progression, including cell proliferation, survival, angiogenesis, invasion, and metastasis

Taking into account the mechanism of protein interaction with the immobilized ions, careful should be taken in IMAC to avoid strong reducing and chelating agents in any of the buffers (as for instance, EDTA), as they will reduce or strip the immobilized metal ions (Carson et al., 2003