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Study Selection: Articles were manually screened for relevance to idiopathic hypersomnia pathophysiology, diagnosis, and treatment and EDS in psychiatric populations

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Some studies have shown that ion channels (such as ATP-dependent K + channels and Ca 2+ -activated K + channels) play a role in adapting to changes in the high-altitude hypoxic environment by altering serum ion levels

As a result, the autoreactive T cells escape death by apoptosis, leave the thymus and become drifting mines in the peripheral lymphoid organs, ready, if activated, to attack and ultimately kill beta cells in the pancreatic islets