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Under most physiological conditions, GSH buffers oxidants in the cytoplasm and mitochondria and supports nuclear repair processes, thereby increasing the threshold for regulated cell death and, in certain pathological settings, contributing to therapy resistance

Multiple studies have demonstrated that testosterone induces OS in the muscle, testis, and human placenta (76)

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20 , 21 Much earlier, Selyes concept was born outside of the gastrointestinal tract, in the adrenal gland, and Selye conceptualized the general syndrome of adaptation (i.e., adrenal gland hypertrophy, thymolymphatic involution, and stomach stress ulcers) to achieve general homeostasis in the whole body while the derangement could explain the genesis of many stress-induced diseases

Abnormally high levels of Substance P in spinal fluid or other neurotransmitters might be a cause, as they transmit and amplify pain signals to and from the brain