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All three treatments were administered as a single subcutaneous dose of 4 mg, to allow proper determination of the PK parameters

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In an in vivo study, the aqueous fraction of Paullinia cupana seeds was repeatedly administered to rats who were then placed in a T-maze, a model of generalized anxiety and panic disorders, and the guarana was shown to have anxiolytic and panicolytic effects [242]

2023;10(13):e2300880

37.0 37.1 37.2 "Ehlers-Danlos syndrome - Diagnosis and treatment - Mayo Clinic"