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Int.Clin Psychopharmacol
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i.p.) prior to injection of the metabolic inhibitor 3-nitropropionic acid (3-NPA) in adult Sprague Dawley rats attenuated the 3-NPA induced increase in expression of the uncoupling protein UCP-2 and dopamine D(1) receptor genes in striatum that were upregulated in response to impaired metabolism [87]
[DOI] [PubMed] [Google Scholar] 43.Maleki V, Jafari-Vayghan H, Kashani A, Moradi F, Vajdi M, Kheirouri S, et al

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The main mechanism of NE inactivation is its presynaptic reuptake via a selective NE transporter, followed by metabolism by monoamine oxidase A (MAO A) and catechol-O-methyltransferase (COMT), with formation of 3-methoxy-4-hydroxyphenylglycol (MHPG), measurable in CSF