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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Uppugunduri C.R.S., Muthukumaran J., Robin S., Santos-Silva T., Ansari M

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doi: 10.2174/1871530322666220627141651 51

This multi-modal strategy costs less than repeated professional-only treatments producing superior long-term outcomes versus topical-only protocols potentially producing incomplete results in moderate to severe cases

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The most adverse effects were observed in the kidney due to a significant increase in the inflammatory biomarkers MCP-1 and IL-6 at a dose of 100 mg/kg bw/day and TNF-, resistin and PAI-1 were significantly increased at a dose of 100 mg/kg bw/day, 100 mg/kg bw/day, and 200 mg/kg bw/day, respectively (Figure 5)