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Rat studies of various tissue injuries consistently show improved healing suggesting bone fractures likely respond similarly

Lancet 357, 15131518

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24 25 Some patients may experience recurrence or worsening of symptoms when the interval between injections is extended or extended too quickly, and report that continuation of frequent intramuscular hydroxocobalamin injections, varying between twice weekly and once every three to four weeks, 65 is needed to remain asymptomatic

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In SH-SY5Y/MYCN cells, (M+D)/2 had no effect on cell death, while (M+D+V)/3 increased toxicity at 48 and 72 hours ( Figure 4A )