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The inhibition of the cystine/glutamate transporter hinders glutathione synthesis and induces ferroptosis, a regulated form of cell death characterized by excessive accumulation of lipid peroxides

Specific therapy for hepatic disease is not usually required, and hepatic damage is reversible with control of sepsis

This is possible only in the presence of a right-left shunt at the level of an open oval window (paradoxical embolism), as well as an embolism substrate (in adult patients, these are blood clots in the varicose veins of the lower extremities).Given the lack of indications for surgical closure of a functioning oval window, the latter is currently not indicated

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Uncontrolled innate and impaired adaptive immune responses in patients with COVID-19 acute respiratory distress syndrome