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Description
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The New England Journal of Medicine, 341, 491-497

In the first step, trimethylamine (TMA) is generated from the dietary nutrients (e.g., choline, phosphatidylcholine, L-carnitine) by the activity of gut microbiota TMA lyases

In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimers disease and other oxidative stress-related neurodegenerative disorders

Inter-reviewer agreement during study selection was assessed using percent agreement

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