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Sirtuin 7 inhibitor attenuates colonic mucosal immune activation in mice-potential therapeutic target in inflammatory bowel disease

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Pollo A, Carlino E, Benedetti F

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[DOI] [PMC free article] [PubMed] [Google Scholar] 166.Mogol, A

First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate