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We can't stress this enough: understanding this distinction is the non-negotiable first step in designing a sound research protocol

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Moreover, reduction in the action of sirtuin coupled with hyperacetylation of histone sites including H3K27, H3K9, and H2BK15 at the PD prefrontal cortex, have been profoundly dysregulated at genomic levels hence associated with the pathology of PD (Park et al., 2016)