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The pulmonary intravascular glycocalyx, composed of hyaluronan (HA), heparan sulfate proteoglycan (HSPG), Syndecan-1, and Glypican-1, degrades during ALI, reducing lung surface protein expression (e.g., VE-Cadherin, Occludin, VCAM-1, E-selectin) (Chen et al., 2021

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Nevertheless, these systems frequently generate proteins in the form of inclusion bodies, requiring extensive and expensive downstream processing steps such as solubilization, refolding, and chromatography

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finally, it holds significant application value in predicting drug resistance (Rosati and Giordano, 2022)

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none have ever shown toxicity

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doi: 10.1038/s41392-024-01772-w

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