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Notably, 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, is elevated in liver biopsy specimens of MASLD patients, and 31 P-MRS imaging has demonstrated ATP depletion consistent with mitochondrial dysfunction [101, 102]

doi: 10.1038/s41564-017-0089-z, 89 Shen-GuntherJ.XiaQ.CaiH.WangY

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Annu Rev Clin Psychol (2008) 4:189216.10.1146/annurev.clinpsy.4.022007.141248 74 HofferA

Previous studies have also demonstrated that vitamin C exerts anti-inflammatory effects through modulation of both adaptive and innate immunity (124, 125)