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Water-soluble contrast is used to avoid barium peritonitis that may result if barium leaks from a perforated diverticulum into the peritoneal cavity
Front Pharmacol 15:1439536
They act on different pathways

Nature 373: 699702 [DOI] [PubMed] [Google Scholar] Schmidt L., Duh F.M., Chen F., Kishida T., Glenn G., Choyke P., et al
