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We found that histone acetylation was rescued by either carnitine or acetyl-carnitine but only weakly by propionyl-carnitine or butyryl-carnitine ( Fig
One such approach involves the use of mitochondrially targeted zinc finger nucleases (mtZFN), a heterodimer nuclease consisting of a DNA binding site (tandem repeat of zinc fingers binding three bases each), and a DNA cleavage domain (a Fok1 endonuclease)
