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also known as alanine, serine, cysteine-preferring transporter 2, ASCT2), and then convert it into glutamate under the action of glutaminase (GLS), and further convert it into -ketoglutarate (-KG), which enters the Tricarboxylic Acid cycle (TCA) and participates in the onset, development and dissemination of tumors [21, 22]

TRIM46 mediated Gpx4 ubiquitination pathway is involved in HG-induced ferroptosis in human RCECs (109)

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XBP1 promotes NRAS(G12D) pre-B acute lymphoblastic leukemia through IL-7 receptor signaling and provides a therapeutic vulnerability for oncogenic RAS

Chao et al., 2023

In contrast, WES focuses on the exonic regions that encode proteins (Georget and Pisan, 2023)