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While in the majority of IBS patients, CNS-related precipitants in early and adult life (e.g., psychological trauma, stress, abuse, maternal neglect) 147 have been identified, about half of IBS patients present after an intestinal trigger 148

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At the same time, more recent reviews emphasise that preclinical data predominate, so interpretation of the results should take into account the experimental nature of the substance and the limited number of high-quality clinical data

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Hybrid supercapacitors (HSCs) cleverly combine a battery-type electrode dominated by Faradaic reactions (providing high energy density) with a capacitor-type electrode dominated by non-Faradaic reactions (providing high power density and long life), and are expected to break through the bottleneck of the energy-power trade-off in traditional energy storage technologies, offering a very promising solution for the development of next-generation energy storage technologies 13,14