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Here's to the next 250 years of discovery

Keywords: opioid receptors, desensitization, tolerance mechanisms, biased signaling, receptor trafficking Introduction Opioids are the most potent drugs used for pain relief

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They are found in all vertebrates and some invertebrates

An in vitro study suggests sumoylation as a post-translational modification of CSE [24]

PMID:10371157 PDF
