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[DOI] [PubMed] [Google Scholar] 158.Keizer H.G., Pinedo H.M., Schuurhuis G.J., Joenje H

In the tumor microenvironment these receptors are engaged by PS or PS bridging molecules resulting in the expression of immunosuppressive cytokines and the prevention of a productive anti-tumor immune response

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In addition to TAMs, the proliferation and metabolic activities of T lymphocytes and B lymphocytes within the TME are also critically dependent on glutamine

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Theoretically, the intracellular assimilation of folic acid via dihydrofolate reductase might enhance thymidylate synthetase by bypassing the methylfolate trap, thereby allowing cellular proliferation to progress temporarily