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In addition, BCAA supplementation also reduced the Firmicutes/Bacteroidetes ratio in middle-aged mice (194)

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Apesar da curta meia-vida plasmtica, os efeitos biolgicos downstream no tecido persistem substancialmente mais tempo, consistente com uma cascata de sinalizao e no com uma simples relao dose-resposta direta

These studies all indicate that combined therapeutic strategies integrating multiple active components through hydrogels show significant advantages over single therapies, making hydrogels a promising biomaterial in IDD treatment

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