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, IL-6, IL-1, TNF-, and PGE2 )and serum lipopolysaccharides levels [216,217,218,219,220] and disrupting the intestinal environment, including reducing the diversity of intestinal microorganisms [216, 217] and fecal SCFAs [216, 217, 221], and regulating intestinal PH value [221] and oxidative stress through glycoxidation (NO, protein carbonyl (PCO), MPO and alkaline phosphatase (ALP)) [220, 221]

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PMID: 23071272

Knockdown of NCOA4 in HT22 cells rescues KA-mediated down-regulation of FTH1 expression [137]

& Frhling, S

Potential Benefits Memory enhancement Learning capacity improvement Potential neurodegenerative support Why researchers are interested: Shows strong potential for long-term cognitive enhancement through structural brain changes