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National Research Council (NRC)

J Stat Softw

In cirrhotic patients, nociceptive pain arises from various sources such as pathological fractures, ascites, splenomegaly, muscle cramps, musculoskeletal diseases like avascular necrosis and septic arthritis, and mastalgia (67, 68, 82)

Based on Surveillance, Epidemiology, and End Results (SEER) data from CCA diagnoses between 2001 and 2017, the estimated 5-year mortality rate is 80.1% (Javle et al., 2022)

[1] [3] Humans synthesize carnitine from the substrate TML (6- N -trimethyllysine), which is in turn derived from the methylation of the amino acid lysine

doi: 10.1016/j.bbrc.2016.11.017 135 GengJYangCWangBZhangXHuTGuYet al