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Description
The pH conflict can denature the peptide and irritate skin
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A summary of these studies is available in Supplementary Table S6 [9,10,11,56,59,71,83,84,85,88,89,90,99,100]

Olive JK, Zhou N, Mitchell KG, Corsini EM, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Antonoff MB
Its a serious concern

Expression of the SLC23A1 gene (SVCT1) is predominantly in intestinal epithelial cells and renal tubular cells where the transporter is found in the apical plasma membrane
