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By sharpening the inclusion criteria in the present study, we expect to reduce heterogeneity of the patient sample, diminish possible confounding effects by other medications and develop a tailored intervention for patients with mood disorder with inflammatory dysregulation who have do not respond to regular phases of antidepressant treatment

After synthesizing the specific biomarkers, a solid-phase extraction protocol and a UHPLC-MS/MS method with isotopic dilution were optimized