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J., Frances D

iPSC-derived human liver organoid culture The iHLOs at various developmental stages were obtained from 3Dnamics, Inc

Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, et al

GDH1-derived AKG directly engages and activates the IKK-NF-B signaling axis, thereby upregulating the expression of the glucose transporter 1 (GLUT1) to promote compensatory glucose uptake and tumor cell survival under low glucose conditions [133]

SREBP-1c is positively regulated by insulin and negatively by AMPK and promotes enzymes, i.e., acetyl-CoA carboxylase (ACC1) and fatty acid synthase (FAS), which are involved in de novo fatty acid synthesis [85,86]

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice