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Thereby, ketamine as the model of schizophrenia in rats [193] (as acute ketamine administration was associated with schizophrenia-like or psychotomimetic symptoms with large effect sizes and an increase in positive and negative symptoms [195,196]) might escape from the extraordinary complexity of extrapolation from animal models of mental disorders in general [197,198,199]

People with MTHFS variants cannot do this efficientlyfolinic acid builds up instead of being metabolized. In a landmark 2018 study, treating MTHFS-deficient patients with folinic acid caused it to accumulate 30-fold and actually worsened their cerebral folate deficiency

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Without adequate B vitamin levels, the bodys ability to metabolise fats, carbohydrates, and proteins is significantly compromised

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10.3390/pharmaceutics14122706 67 JeongJ.LeeH.ChoiJ.KangJ.KimD.ParkC.et al (2025)