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Mechanistically, fragmentation reduces malonyl-CoA inhibition of CPT1, while elongation increases CPT1 sensitivity to malonyl-CoA inhibition
Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation
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10.1093/humupd/dmv021 36 GamulinO.SerecK.BiliV.BalarinM.KosoviM.DrmiD.et al (2013)
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