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These optimistic clinical outcomes were validated in individuals with concurrent IBS-D, stress, and depression by a randomized controlled study (RCT) (262)

On adipocytes of white and brown adipose tissue, Hcar2 acts as a metabolite sensor, inhibiting lipolysis in times of fasting and contributing to the lipid-modifying effects of niacin [58, 63]

Week A Day 1: 500mg NAD IV ( 2-3.5 hrs) Day 4: 100mg NAD SQ Day 6: 100mg NAD SQ Daily: 500mg NR/NMN in the morning Week B Daily: 500mg NR/NMN in the morning Day 1: 100mg NAD SQ Day 4: 100mg NAD SQ Day 6: 100mg NAD SQ Use this cycle and keep repeating, modifying it as you see fit

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Hennig GW, Gould TW, Koh SD, Corrigan RD, Heredia DJ, Shonnard MC, Smith TK (2015) Use of genetically encoded calcium indicators (GECIs) combined with advanced motion tracking techniques to examine the behavior of neurons and glia in the enteric nervous system of the intact murine colon