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doi: 10.1161/HYPERTENSIONAHA.116.08015

Through SIRT1 activation and suppression of the NF-B and MAPK cascades, polyphenols attenuate inflammatory gene expression and cytokine release, reducing TNF-, interleukin-1 (IL-1), and IL-6 production while maintaining endothelial nitric oxide synthase (eNOS) activity and nitric oxide bioavailability [36,38,199]

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PMID: 53 KramHProkopGHallerBGemptJWuYSchmidt-GrafFet al