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P389 Vandenput L
Pharmacol Rep 68:570581 Bloem BR, Okun MS, Klein C (2021) Parkinsons disease
--- The Clinical Frontier The strongest human evidence now supports: Metformin (metabolic reprogramming) NAD boosters (mitochondrial repair) MSC infusions & TPE (cellular rejuvenation) GLP-1 agonists (metabolic efficiency) The future lies in combination strategies integrating metabolism, cellular repair, and mitochondrial support for multimodal rejuvenation
On one hand, the myelinated sensory nerve fibers lose their function
Prior to disease onset neutrophils enable permeability of the blood-brain-barrier (BBB) and subsequent infiltration of the central nervous system (CNS) by leukocyte populations
This profound deficiency indicates that the brain is under severe, unmitigated oxidative stress
