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High-density lipoproteins (HDL) and apolipoprotein C1, a component of HDL, enhance HCVpp infectivity in an SR-BI-dependent manner 87,92

To understand how these distal regulatory elements specifically regulate gene expression, more detailed functional validation and mechanistic studies are required

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Moreover, we explore the state of the art in the technological field of treating this fundamental symptom from current definitions to diagnosis and discuss procedures used in daily practice (clinical evaluation, EDSS, cognitive and neuropsychological tests)

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