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These drugrelated adverse events included increased hepatic transaminases (4% and 3% for low and high dose, respectively), hypercalcemia (3% and 3% for low and high dose, respectively), and fatigue (1% and 1% for low and high dose, respectively) (Palmieri et al., 2024)

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some treatments have limited efficacy

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Therefore, HGF creates a microenvironment through interaction between cancerous cells and adjacent stroma, increasing the further development and invasiveness of cancer [19]