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The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus

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However, even under inflammation-associated hypoxia, the remaining oxygen in the intestinal tissue is sufficient to support mitochondrial oxidative phosphorylation (OXPHOS) 15 , and these changes cannot explain the complex and early (before onset of histological inflammation) alterations in epithelial metabolism observed in intestinal inflammation 13,18,20

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