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Indeed, knockdown of ABHD5 reduces both basal and stimulate lipolysis in adipocytes (31) (Figure 1)

This comprehensive laboratory surveillance helps rule out organ toxicity or bone marrow suppression that might occur with extended exposure

What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug