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The selection of this type of mice was based on the previous studies on mice with EIF (Jinchun and Jie, 2011
A break of 4-8 weeks is recommended before starting a new cycle
PLoS Genet 9: e1003711 Skerrett R, Malm T, Landreth G (2014) Nuclear receptors in neurodegenerative diseases
It is likely that this imposed stress is pertinent to dry eye induced ocular pain even though in these patients the hyperosmotic threshold for inducing pain through TRPV1 activation is unclear [29]
