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At present, it is merely a theoretical framework for promoting further research and discussion, and should not be used as a basis for clinical decision-making

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In a broad variety of cancers, GSTs are involved in the resistance to several anticancer drugs by their conjugating activity (some examples are reported below)

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While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers