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Also, mitogen-activated protein kinase (MAPK) signaling is associated with mitochondrial homeostasis, MAPK1/3 potently inhibit mitochondrial biogenesis (Zhu et al., 2012)
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In vivo study demonstrated that topical application of OPs on the skin significantly alleviated moisture loss, epidermal hyperplasia, as well as degradation of collagen and elastin fibers caused by chronic UVB irradiation
doi: 10.1126/science.3798116
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Verma D, Kantarjian H, Shan J, O'Brien S, Estrov Z, Garcia-Manero G, Koller C, Borthakur G , Cortes J
