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The Best-1 channels are localized in astrocytic leaflets and are opened by relatively moderate increases in [Ca 2+ ] i at the resting membrane potential 89

These include the regulation of inflammation, promotion of cell migration and fibroblast proliferation, stimulation of collagen synthesis, enhancement of angiogenesis, and remodeling of the ECM [24, 32-36, 58-60]

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These findings underscore FSP1s independent role in tumor maintenance and its potential as a stand-alone therapeutic target

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