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Description
Altered intercellular communication

Riha C, Guntensperger D, Kleinjung T, Meyer M

Autism Research and Treatment, 2012, 986519

doi: 10.1002/advs.202309517 133 ZilleMKaruppagounderSSChenYGoughPJBertinJFingerJet al
Das natrliche Molekl kommt in fast allen Zellen vor, wo es die Neubildung von Blutgefssen, die Zellmigration und die Reparatur von Gewebe steuert

Structurally, IRS proteins are defined by phosphotyrosine binding (PTB) and pleckstrin-homology domains located in the N-terminal region, which are required for their interaction with phosphorylated insulin receptor and targeting to the plasma membrane, and by multiple tyrosine residues in the mid- and C-terminal regions, which are phosphorylated by activated insulin receptor and serve as docking sites for proteins containing SH2 domains [13]
