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The Jianwei Shoutai Pill demonstrated an ability to attenuate ferroptosis both in vivo and in vitro through mechanisms that involve reducing iron accumulation, lipid peroxidation, and reactive oxygen species, while simultaneously enhancing antioxidant defenses via increased expression of GPX4 and SLC7A11

Additional, supplementation of sodium pyruvate and JX06 in GGCT-knockdown cells confirmed that this regulatory effect of GGCT-mediated changes in ROS was independent of energy metabolism pathways

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This absorption challenge has led researchers to explore alternative delivery methods, with liposomal technology emerging as the most promising solution for enhancing glutathione bioavailability