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In addition to fatigue and chronic pain as the prime symptoms, individuals may experience an array of symptoms such as post-exertional malaise, unrefreshing sleep, cognitive impairments commonly known as brain fog, orthostatic intolerance, and gastrointestinal complaints [7,8,9]

Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, et al

By slowing gastric emptying and enhancing feelings of fullness, it helps reduce overall caloric intake

Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

In addition, mechanisms need to be established by which Stevia sweetener reduces food intake and lowers total cholesterol, triacylglycerides, and low-density lipoproteins