glutathione s transferase review article The role of S-transferases in human disease pathogenesis and their current inhibitors Functional and Structural Diversity of

10.4254/wjh.v12.i9.596 80 MiyazawaK.MiyazonoK

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Its efficacy in mitigating iron overload-induced ferroptosis by decreasing excessive iron and lowering lipid peroxidation in the retina through an NFE2L2-mediated mechanism, ameliorates retinal pathology, increases retinal cell viability, protects against ferroptotic changes in mouse models, which highlights its potential as a novel approach in managing retinal degeneration (Song et al., 2024)