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The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats

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Specifically, under PF conditions, increased ER stress in AEC2 resulted in impaired lipid synthesis, in particular a reduction in unsaturated fatty acid synthesis mediated by stearoyl coenzyme A desaturase 1 (SCD1) Reduced SCD1 activity not only impeded resolution of endoplasmic reticulum stress, but also exacerbated cellular dysfunction, thereby triggering a fibrotic response (Romero et al., 2018a)

Beck JD, Andreeff M , Haghbin M, Miller DR, Tan C, Good RA, Gupta S
