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Also, in the presence of Fe2+ it is converted to deleterious hydroxyl radical (OH) through Fenton reaction

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ARA-290, a nonerythropoietic erythropoietin-derived peptide, reduces neuropathic pain

The recombinant protein retained Lys-PG hydrolase activity (Supplementary Fig

1C), suggesting that cystine starvation induced the amino acid response but not the ER stress signaling within the ISR

Potential therapies Although some researchers have attempted to establish a treatment for ME/CFS and no reproducible results have been found (60), some treatments seem promising in ME/CFS ( Figure 13 )