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Because the liver is responsible for filtering everything you ingest, it is constantly exposed to oxidative pressure

While low-level ROS assist host defense by clearing pathogens, sustained overproduction causes oxidative stress that exacerbates tissue damage [407]

Functional GTP cyclohydrolase 1 exists as a homodecamer that consists of two tightly associated dimers that each comprise a pentameric complex of the GTP cyclohydrolase 1 monomers

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Hamad GM, et al