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Description
[33] demonstrated that NNMT expression is upregulated in WAT of humans with insulin resistance or T2D and that plasma MNA levels are significantly and positively correlated with NNMT expression in WAT and with the degree of insulin resistance
Protocols, doses, and reactions reported below come from published clinical trials and self-reported community sources
It turns out that even in mice that lack these receptors, fat loss takes place when AOD9604 is administered Though the beta-3-adrenergic receptor likely plays a role in fat loss secondary to AOD9604, at least one other mechanism must be in play as well

Reported weekly weight-loss differences over placebo were small (in the range of -0.06 to -0.15 kg/week, depending on dose)
Keep the calorie intake below 50% of the actual need for optimum fat loss

L.BentleyE.RubtsovD
