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It works as cellular fuel, converting food into energy through a process called mitochondrial respiration

Cell (2017) 168:65769

Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells

Jenner et al., 1992

Importantly, NO generated by iNOS inhibits the polarization of M1-type macrophages to M2-type macrophages induced by interleukin-4 (IL-4) [32]
