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For example, gene expression studies often rely on housekeeping genes to normalize the number of cells in a given sample and matrices, such as tears or urine, differ in concentration or volume due to biologic variation, and as such may require an internal normalization factor, such as total protein or creatinine, respectively
GH/AMPK), making it complementary
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36,37 Zonula occludens (ZO), including ZO-1 and its homologs ZO-2 and ZO-3, is a group of PDZ-related scaffolding proteins that belong to the superfamily of membrane-associated guanylate kinase-like proteins, possessing sites of three tandem PDZ domains at the N-terminus 38,39 (Figure 1)
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