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The development of single-inhibitor with multi-target drugs is expected to improve efficacy through synergistic effects while reducing side effects

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For example, GSTO1-1 interacts with AKT and MEK1/2, activating AKT signaling in human neuroblastoma cells (33)

PQ is metabolized by cellular enzyme systems including the NADPH-cytochrome P450 reductase (Clejan and Cederbaum, 1989) and NADPH oxidase (Bus and Gibson, 2009)

Individuals having variants associated with acute hemolysis may have a significant fall in hemoglobin concentration requiring a RBC transfusion