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PLGA with a copolymer ratio 50:50 (Mw = 50 kDa) and PCL (Mw = 70 kDa) were purchased from Esun Industrial Company, China

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This shift toward a more granule-rich somatotroph phenotype suggests that Ipamorelin may gradually remodel the functional state of the GH-producing cell population rather than simply triggering acute release

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AGEs are known to covalently modify proteins bringing about loss of functional alteration in the proteins